What question did this study set out to answer?

To identify the specific common genetic variants and genomic regions responsible for the heritability of human height across diverse ancestral populations.

October 12, 2022Faculty publicationsOpen Access

A saturated map of common genetic variants associated with human height

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Authors

LYLoïc YengoThe University of Queensland SVSailaja VedantamBroad Institute EMEirini MarouliQueen Mary University of London

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Implication

Genome-wide association study uncovers 12,111 common variants capturing height heritability across diverse ancestries, highlighting genomic saturation in European populations.

Key Points

To identify the specific common genetic variants and genomic regions responsible for the heritability of human height across diverse ancestral populations.
Conducted a genome-wide association study analyzing genetic and phenotypic data from 5.4 million individuals across diverse ancestries.
Evaluated the clustering of trait-associated variants into distinct genomic segments and assessed out-of-sample phenotypic prediction across different ancestries.
Identified 12,111 independent SNPs spanning 7,209 genomic segments (covering ~21% of the genome) that explain nearly all common SNP-based heritability of height.
Identified variants accounted for 40% of phenotypic variance in European-ancestry populations but only 10–20% in populations of non-European ancestries, driven by differences in linkage disequilibrium and allele frequencies.

Cite This Study

Yengo et al. (2022) studied this question.

synapsesocial.com/papers/694a05a89fc42bc040774574 https://doi.org/10.1038/s41586-022-05275-y

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Implication

Genome-wide association study uncovers 12,111 common variants capturing height heritability across diverse ancestries, highlighting genomic saturation in European populations.

A saturated map of common genetic variants associated with human height

Discussion

Member takes

Implication

Key Points

Cite This Study

A saturated map of common genetic variants associated with human height

Discussion

Member takes

Implication

Key Points

Cite This Study

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