Finds long-term hormonal changes persist after weight loss, suggesting need for new strategies to prevent relapse.
One year after initial weight reduction, levels of the circulating mediators of appetite that encourage weight regain after diet-induced weight loss do not revert to the levels recorded before weight loss. Long-term strategies to counteract this change may be needed to prevent obesity relapse. (Funded by the National Health and Medical Research Council and others; ClinicalTrials.gov number, NCT00870259.).
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Sumithran et al. (2011) studied this question.
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