What question did this study set out to answer?

The research aims to develop a regioselective method for C–H functionalization of 2-arylbenzo[ f ]isoquinoline.

January 6, 2026RSC Advances0 citationsOpen Access

Directing group-assisted C–H functionalization of 2-arylbenzo f isoquinoline: a robust route to decumbenine B analogues with photophysical applications

SMSampa MondalSaha Institute of Nuclear Physics SGSudipta GharaMaulana Abul Kalam Azad University of Technology, West Bengal SASk Abulkalam AzadMaulana Abul Kalam Azad University of Technology, West Bengal

Key Points

The research aims to develop a regioselective method for C–H functionalization of 2-arylbenzo[ f ]isoquinoline.
Utilized Ru/Pd/Cu catalyst for C–H functionalization of 2-arylbenzo[ f ]isoquinoline.
Synthesis of Decumbenine B analogues was performed with regioselective functional groups: –CH2OH, –Br/Cl, –SePh.
Conducted DFT studies for metal selection.
Successfully synthesized Decumbenine B analogues through C–H functionalization.
Demonstrated applicability of the developed method in photophysical contexts.
Indicated potential for toxic-compound sensing based on DFT studies.

Abstract

A regioselective C–H functionalizations –CH 2 OH, –Br/Cl and –SePh) via Ru/Pd/Cu catalyst has been developed for the synthesis of Decumbenine B analogues. DFT studies for metal selection and toxic-compound sensing are attraction of this protocol.

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