Influence of intramolecular interactions and transition state energetics on the strain-promoted azide–alkyne cycloaddition of 2-aminobenzenesulfonamide-containing cyclononynes | Synapse
Influence of intramolecular interactions and transition state energetics on the strain-promoted azide–alkyne cycloaddition of 2-aminobenzenesulfonamide-containing cyclononynes
This research examines how intramolecular interactions affect the azide-alkyne cycloaddition reaction.
Analyzed cyclononynes containing 2-aminobenzenesulfonamide with a Boc protection group.
Studied transition state energetics and intramolecular hydrogen bonding.
Compared calculated product ratios with experimental results.
Intramolecular hydrogen bonds are retained in the transition state.
Calculated product ratios align with experimental findings.
Abstract
When a Boc-protected cyclononyne reacts, intramolecular hydrogen bonds are retained in the transition state. The calculated product ratios align with experimental findings.