This feature article reviews advances in the delivery of PROTACs using nanoparticles for controlled protein degradation.
Review of recent literature on nanoparticle-enabled delivery systems.
Discussion of the mechanisms of spatiotemporal control in protein degradation.
Examination of applications of PROTACs in therapeutic contexts.
Nanoparticle delivery increases the effectiveness of PROTACs for targeting proteins.
Spatiotemporal control enhances the precision of protein degradation.
The advances highlight significant potential for therapeutic applications in various diseases.
Abstract
This feature article highlights the most recent advances in nanoparticle-enabled delivery of proteolysis-targeting chimeras (PROTACs) for spatiotemporally controlled protein degradation.