A 2nd-Generation Scalable Synthesis of the HIV-1 Entry Inhibitor CJF-III-288 Enabled by Photoredox Catalysis

Key Points

• To develop an efficient synthesis process for the HIV-1 entry inhibitor CJF-III-288.
• Implemented a 2nd-Generation synthesis process.
• Utilized photoredox catalysis for the synthesis of CJF-III-288.
• Eliminated the use of noble metals in the synthesis route.
• Achieved a scalable synthesis of CJF-III-288.
• The process improved efficiency and cost-effectiveness.