What question did this study set out to answer?

To assess the toxicity of linezolid in children with drug-resistant tuberculosis in South Africa.

January 6, 2026The Pediatric Infectious Disease Journal0 citations

Linezolid Toxicity in South African Children With Rifampicin-resistant Tuberculosis

SHSacha HornUniversity of Wisconsin–Madison LLLouvina E. van der LaanDesmond Tutu HIV Foundation HSH. Simon SchaafDesmond Tutu HIV Foundation

Key Points

To assess the toxicity of linezolid in children with drug-resistant tuberculosis in South Africa.
Prospective cohort study of South African children treated with linezolid.
Common side effects such as anemia and peripheral neuropathy were monitored.
Management strategies for severe adverse events were noted.
Anemia and thrombocytopenia were common among treated children.
Peripheral neuropathy was noted as a typical side effect after three months of treatment.
Grade 3/4 events often required active management.

Abstract

There is little evidence about linezolid-attributed toxicity in children with drug-resistant tuberculosis. In a prospective cohort of South African children treated with linezolid, anemia, thrombocytopenia and peripheral neuropathy were common, sometimes severe, and often required active management. Peripheral neuropathy and grade 3/4 events typically occurred after ≥3 months of treatment.

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