Engineering ε -polylysine-based photodynamic therapy agents with oxygen carrying and membrane-targeting capabilities for enhanced therapy under hypoxic conditions

Key Points

• The aim is to enhance photodynamic therapy by engineering ε-polylysine-based agents for use in hypoxic environments.
• Developing ε-polylysine-based photodynamic therapy agents.
• Incorporating oxygen carrying and membrane-targeting features.
• Testing the agents' effectiveness under hypoxic conditions.
• Demonstrated enhanced therapeutic effects of ε-polylysine-based agents in hypoxia.
• Increased oxygen availability improved the efficacy of photodynamic therapy.