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January 1, 2026RSC Medicinal Chemistry

Unlocking the therapeutic potential of HDAC8-degrading PROTACs: progress, challenges, and future directions

Suvankar Banerjee Nilanjan Adhikari Balaram Ghosh

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Key Points

This work aims to explore the therapeutic potential of HDAC8-degrading PROTACs and outline associated challenges.
Review of HDAC8-degrading PROTACs discovery timeline
Analysis of current progress and challenges in the field
Identified several key challenges in developing effective HDAC8-degrading PROTACs
Highlighted potential therapeutic applications of these PROTACs

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Implication

Progress on HDAC8-degrading PROTACs reveals challenges, indicating new therapeutic potential for targeting diseases.

Abstract

Discovery timeline of HDAC8-degrading PROTACs.

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Cite This Study

Banerjee et al. (2026) studied this question.

synapsesocial.com/papers/695d855e3483e917927a4cda https://doi.org/10.1039/d5md00871a

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Abstract 3236: Discovery of hydrazide-based HDAC8 selective PROTACs2024
2Advances in the Design and Development of PROTAC-mediated HDAC DegradationOriginal Research · 2021 · 21 citations
3Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors2024 · 21 citations
4Epigenetic therapy meets targeted protein degradation: HDAC-PROTACs in cancer treatment2025 · 9 citations
5Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC82024 · 23 citations

Histone Deacetylase Meets Protein Degradation: Accelerating Anticancer Drug Discovery2026
Rapid Two-StepMulticomponent Synthesis and Structure-degradationRelationships of Selective HDAC6 PROTAC Degraders2026
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity2022
Research process of iminosugars in glycosidase inhibition and hypoglycemic activityRSC Medicinal Chemistry · 2026
Rational design of an environment-sensitive fluorescent probe for monitoring butyrylcholinesterase activity and its application in Alzheimer's diseaseRSC Medicinal Chemistry · 2026

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