Unlocking the therapeutic potential of HDAC8-degrading PROTACs: progress, challenges, and future directions

Key Points

• This work aims to explore the therapeutic potential of HDAC8-degrading PROTACs and outline associated challenges.
• Review of HDAC8-degrading PROTACs discovery timeline
• Analysis of current progress and challenges in the field
• Identified several key challenges in developing effective HDAC8-degrading PROTACs
• Highlighted potential therapeutic applications of these PROTACs