What question did this study set out to answer?

Investigate the association of recombinant human soluble thrombomodulin with in-hospital mortality in acute pancreatitis patients with disseminated intravascular coagulation.

January 6, 2026Critical Care Medicine

Recombinant Human Soluble Thrombomodulin and In-Hospital Mortality in Acute Pancreatitis With Disseminated Intravascular Coagulation: A Japanese Nationwide Study

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Authors

HOHaruka OkadaKeio University MHMasayasu HoribeKeio University YSYusuke SasabuchiJichi Medical University

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Implication

Retrospective cohort study shows lower in-hospital mortality with recombinant human soluble thrombomodulin in acute pancreatitis, suggesting clinical benefit.

Key Points

Investigate the association of recombinant human soluble thrombomodulin with in-hospital mortality in acute pancreatitis patients with disseminated intravascular coagulation.
National retrospective cohort study using Japanese Diagnosis Procedure Combination database.
Patients hospitalized with acute pancreatitis and DIC were analyzed from July 2010 to March 2022.
Propensity score matching created balanced groups for those receiving rTM and those not receiving it.
Overall, 10,238 patients with acute pancreatitis and DIC were included.
In-hospital mortality was 15.5% in the rTM group versus 19.7% in the non-rTM group.
The risk difference was -4.2% with a risk ratio of 0.79, indicating a significant reduction in mortality.

Cite This Study

Okada et al. (2026) studied this question.

synapsesocial.com/papers/695d85653483e917927a4f0f https://doi.org/10.1097/ccm.0000000000007009

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Implication

Retrospective cohort study shows lower in-hospital mortality with recombinant human soluble thrombomodulin in acute pancreatitis, suggesting clinical benefit.

Recombinant Human Soluble Thrombomodulin and In-Hospital Mortality in Acute Pancreatitis With Disseminated Intravascular Coagulation: A Japanese Nationwide Study

Discussion

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Implication

Key Points

Cite This Study

Recombinant Human Soluble Thrombomodulin and In-Hospital Mortality in Acute Pancreatitis With Disseminated Intravascular Coagulation: A Japanese Nationwide Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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