This research aims to identify new targets that influence opioid sensitivity through genetic interactions.
Conducted experiments on mice to assess their response to opioids
Analyzed time-dependent epistatic interactions
Evaluated the role of intracellular fibroblast growth factors on opioid sensitivity
Identified epistatic interactions that vary over time affecting opioid responses
Discovered intracellular fibroblast growth factors influence sensitivity to opioids
Abstract
Experiments reveal that a time-dependent epistatic interaction influences how mice respond to opioids, and that intracellular fibroblast growth factors also influence opioid sensitivity.