Internal probe-external recognition immunosensor fabricated on nanochannels for reagent-free electrochemical detection of interleukin-1β

Key Points

• To develop an immunosensor for reagent-free detection of interleukin-1β.
• Developed an internal probe-external recognition immunosensor on a nanochannel array.
• Separated signal generation from target recognition to enhance detection.
• Utilized electrochemical methods for label-free detection.
• Successfully detected interleukin-1β using the fabricated immunosensor.
• Demonstrated enhanced sensitivity in detecting IL-1β compared to traditional methods.