What type of study is this?

This is a Randomized Controlled Trial study.

What question did this study set out to answer?

This research evaluates the safety and tolerability of dried kratom leaf powder in healthy volunteers.

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This research evaluates the safety and tolerability of dried kratom leaf powder in healthy volunteers.
Randomized, double-blind, placebo-controlled trial
Involving 116 healthy adult volunteers
Participants received single and multiple doses of kratom powder
Evaluation over a 47-day period
No serious adverse events reported
TEAEs like dizziness and nausea increased with higher doses
Alanine aminotransferase levels increased in some participants
Kratom powder showed no meaningful abuse potential or withdrawal symptoms

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Randomized trial shows that kratom powder is safe and well tolerated in healthy adults, suggesting low abuse potential and minimal adverse events.

Huestis et al. (2026) studied this question.

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Randomized trial shows that kratom powder is safe and well tolerated in healthy adults, suggesting low abuse potential and minimal adverse events.