⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

January 1, 2026Organic Chemistry Frontiers

Piezocatalyzed Cascade Cyclization of 1,7-Enynes with α-Keto Acids under Ball Milling

Yi Liu Heng Li Yan Liu Bingxin Yuan

View at Publisher

Ask AI

Bookmark

Share

Key Points

To explore a new method for synthesizing fused pyran motifs, which are important in bioactive compounds and pharmaceuticals.
Utilized piezocatalyzed reactions under ball milling conditions.
Investigated the cyclization of 1,7-enynes with α-keto acids.
Compared effectiveness with traditional synthetic methods.
Demonstrated efficient formation of fused pyran motifs.
Provided an alternative to Fe-catalyzed annulation and photocatalytic approaches.
Showed significant improvements in reaction conditions and yields.

Implication

Cascade cyclization shows promise for synthesizing heterocycles in drug development, suggesting a novel approach with piezocatalytic methods.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/695d856e3483e917927a5221 https://doi.org/10.1039/d5qo01278c

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Novel Synthetic Approaches for the Tandem Cyclization of 1,6‐EnynesReview · 2026
2Selective synthesis of 4,5-dihydropyrenes by a Brønsted acid-catalyzed cyclization cascade of biphenyl-embedded enynes2025 · 1 citations
3Pd-Catalyzed Regiodivergent Cascade Cyclization of 1,8-Enyne Oxime Ethers: Access to Fused Oxepane/Oxocine Based ScaffoldsOriginal Research · 2026
4Pathway-divergent coupling of 1,3-enynes with acrylates through cascade cobalt catalysis2024 · 24 citations
5Novel Synthetic Strategies and Mechanistic Insights Into the Tandem Cyclization of 1,5‐EnynesReview · 2026

Nickel-Catalyzed Enantioselective Cyclizative Alkylation of 1,6-Enynes with Diazo Compounds and Alkyl Halides2026
Asymmetric Cascade Cyclization of Enynamides with Photogenerated Ketenes via Relay Gold and <i>N</i>-Oxide Catalysis2024
Enantioselective Cascade Annulation of 1,2,3-Triazoles and Enals Enabled by Sequential Rhodium and Oxidative NHC Catalysis Involving Cleavage, Migration, and Cyclization2025
Metal-free regio- and chemoselective sulfonocyclization of tertiary enamides to access nobenzene-fused medium-sized rings via SO2 insertionOrganic Chemistry Frontiers · 2026
Tridentate PyMPAA Ligands Enable Efficient Pd-Catalyzed Non-Directed Arene DeuterationOrganic Chemistry Frontiers · 2026

More from Organic Chemistry Frontiers