Features of adipokine-mediated myocardial injury in patients with ST-segment elevation myocardial infarction

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This research aims to analyze the impact of adipokines on myocardial injury in obese patients with ST-elevation myocardial infarction.
Single-centre prospective cohort study including 120 patients with ST-segment elevation myocardial infarction.
Participants divided into groups based on body mass index: excess body weight, obesity, and normal weight.
Analysis of leptin levels, troponin I, and other cardiovascular indices using laboratory and instrumental methods.
Obese patients exhibited the highest levels of leptin (57.27 ng/mL) and troponin I (4.09 ng/mL).
A strong correlation was found between body mass index and leptin (r = 0.87; p < 0.001).
Multiple regression analysis identified body mass index, SYNTAX score, and reduced ejection fraction as independent predictors of troponin I levels.

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Prospective cohort study shows correlation between leptin, obesity, and myocardial injury severity in patients with acute coronary syndrome.

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Vladyslav Kovalenko (2025) studied this question.

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