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Tutorial review examines the mode of action of fluorinated pharmaceuticals, highlighting the significant role of fluorine substitution in enhancing drug potency and therapeutic development.
It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
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Purser et al. (2007) studied this question.
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