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December 13, 2007Chemical Society Reviews

Fluorine in medicinal chemistry

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Authors

SPSophie PurserPMPeter R. MooreSSSteve Swallow

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Overview

Tutorial review examines the mode of action of fluorinated pharmaceuticals, highlighting the significant role of fluorine substitution in enhancing drug potency and therapeutic development.

Key Points

  • To review prominent fluorinated therapeutics and clarify the mechanistic role and impact of fluorine substitution on drug potency and design.
  • Surveyed representative fluorinated drugs across therapeutic applications to assess pharmacological performance.
  • Evaluated the biochemical modes of action and physicochemical changes induced by introducing fluorine into lead compounds.
  • Identifies fluorine substitution as an effective strategy to significantly modulate drug potency, metabolic stability, and target binding affinity.
  • Demonstrates the continuing therapeutic utility of fluorinated scaffolds in generating advanced lead compounds for drug discovery.

Cite This Study

Purser et al. (2007) studied this question.

synapsesocial.com/papers/695ea2ec44e143fbc8d6b2d0https://doi.org/10.1039/b610213c
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