What question did this study set out to answer?

Summarize progress in cross-dehydrogenative coupling strategies that selectively construct carbon-carbon bonds directly from two different carbon-hydrogen bonds under oxidative conditions.

November 8, 2013Angewandte Chemie International Edition

The Cross‐Dehydrogenative Coupling of CH Bonds: A Versatile Strategy for CC Bond Formations

View Full Paper

Ask AI

Bookmark

Authors

SGSimon A. GirardAnsys (Canada)TKThomas KnauberPfizer (United States)CLChao‐Jun LiUniversity of Notre Dame

Discussion

Member takes

Implication

Review highlights advances in oxidative cross-dehydrogenative coupling of diverse C-H bonds, demonstrating waste-minimized pathways for direct C-C bond synthesis.

Key Points

Summarize progress in cross-dehydrogenative coupling strategies that selectively construct carbon-carbon bonds directly from two different carbon-hydrogen bonds under oxidative conditions.
Synthesized research over the past decade regarding oxidative C-C bond-forming methodologies.
Evaluated mechanisms involving in situ dual C-H bond activation without prior substrate prefunctionalization.
Cross-dehydrogenative coupling provides direct, selective C-C bond formation with substantially lower byproduct waste than traditional cross-coupling reactions.
In situ activation of both coupling partners offers a versatile, atom-economical framework for synthesizing diverse organic architectures.

Cite This Study

Girard et al. (2013) studied this question.

synapsesocial.com/papers/695ea4b4fbb090037955df15 https://doi.org/10.1002/anie.201304268

View Full Paper

Ask AI

Bookmark

Implication

Review highlights advances in oxidative cross-dehydrogenative coupling of diverse C-H bonds, demonstrating waste-minimized pathways for direct C-C bond synthesis.

The Cross‐Dehydrogenative Coupling of CH Bonds: A Versatile Strategy for CC Bond Formations

Discussion

Member takes

Implication

Key Points

Cite This Study

The Cross‐Dehydrogenative Coupling of CH Bonds: A Versatile Strategy for CC Bond Formations

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider