Automated titanium fasteners reduced the risk of prosthetic dehiscence by 66% compared to hand-tied knots in mitral valve surgery (adjusted sub-hazard ratio 0.34, p = 0.033).
Does the use of automated titanium fasteners reduce prosthetic dehiscence requiring reintervention in adult patients undergoing mitral valve surgery compared to conventional hand-tied sutures?
The use of automated titanium fasteners in mitral valve surgery is associated with a significantly lower risk of prosthetic dehiscence requiring reintervention compared to hand-tied knots, without increasing mortality or stroke risk.
Absolute Event Rate: 0% vs 0%
Abstract OBJECTIVES This study aimed to assess long-term outcomes of automated titanium fasteners versus hand-tied knots in mitral valve surgery. METHODS In this retrospective, single-center analysis, 2678 adult patients who underwent mitral valve repair or replacement between November 2008 and November 2024 at the Medical University of Vienna were included. Patients were grouped according to the suture-securing technique used: automated titanium fasteners vs hand-tied knots. The primary end-point was prosthetic dehiscence (either mitral annuloplasty ring or valve replacement prosthesis) requiring reintervention. Secondary end-points comprised ischaemic stroke, intracranial bleeding, and all-cause mortality during the follow-up period. RESULTS Among the study population, 1072 (40%) underwent mitral valve surgery using an automated titanium fastener device, and 1606 (60%) with conventional hand-tied sutures. A total of 31 patients (1.2%) had prosthetic dehiscence during the follow-up period. The risk of prosthetic dehiscence was significantly lower in the automated titanium fastener group in both univariable (crude sub-hazard ratio 0.32, 95% confidence interval 0.12–0.86, p = 0.023) and multivariable competing risk regression analysis (adjusted sub-hazard ratio 0.34, 95% confidence interval 0.12–0.91, p = 0.033). Automated titanium fastener group was not associated with an increased risk of ischaemic stroke (adjusted sub-hazard ratio 0.92, 95% confidence interval 0.67–1.27, p = 0.600), intracranial bleeding (adjusted sub-hazard ratio 0.89, 95% confidence interval 0.52–1.52, p = 0.675), or all-cause mortality (adjusted hazard ratio 0.93, 95% confidence interval 0.74–1.18, p = 0.559). CONCLUSIONS The use of an automated titanium fastener device seems to be associated with a lower risk of prosthetic dehiscence in mitral valve surgery. Due to the limited number of prosthetic dehiscence events, and the potential for residual confounding, the results should be interpreted with caution.
Kahrovic et al. (Fri,) reported a other. Automated titanium fasteners reduced the risk of prosthetic dehiscence by 66% compared to hand-tied knots in mitral valve surgery (adjusted sub-hazard ratio 0.34, p = 0.033).