Oral administration of BDG significantly enhances the immune response and increases survival rates against FMDV in vaccinated mice.
Does oral administration of β-D-glucan enhance the immune response to intramuscular FMD vaccination in mice and pigs?
Oral administration of β-D-glucan enhances systemic and mucosal immune responses to intramuscular FMD vaccination in mice and pigs.
Absolute Event Rate: 100% vs 40%
Background Foot-and-mouth disease (FMD) is a viral disease primarily affecting livestock. Although vaccination is the main strategy to control FMD, current commercial FMD vaccines have major drawbacks, such as low antibody titers and short antibody titer maintenance periods. We hypothesized that these shortcomings were caused by low systemic immune induction and the absence of mucosal immune induction by the FMD vaccine. Methods To address the limitations, we enhanced adaptive immune responses through the oral administration of β-D-glucan (BDG). We evaluated the systemic and mucosal immune response of the BDG-fed group (BDG intake + FMD vaccine) and control groups (FMD vaccine) in vivo and ex vivo using mice and pigs. Results The results showed that the oral administration of BDG induced long-term antibody and virus-neutralizing antibody titers in mice and pigs through robust cellular and humoral immunity. We showed that the BDG intake stimulates secretory IgA production in mice and pigs. We also showed that mucosal and systemic immunity-related genes were upregulated by the BDG intake. Conclusion In this study, we provide evidence that the oral administration of BDG improves the overall efficacy of the FMD vaccine by inducing mucosal immunity, which enhances systemic immunity, leading to robust cellular and humoral immune responses in the host. This study is relevant to the establishment of new FMD vaccination strategies, programs, and policies and will contribute to improving field challenges.
Kim et al. (Thu,) conducted a other in Foot-and-mouth disease. Oral β-D-glucan (BDG) vs. FMD vaccine only was evaluated on Survival rates and long-term immune response (antibody titers and VN titers) against FMDV infection. Oral administration of BDG significantly enhances the immune response and increases survival rates against FMDV in vaccinated mice.