Key result
The FMD vaccine containing beta-D-glucan provided 100% survival in mice and complete protection against clinical symptoms in pigs following FMDV challenge, outperforming conventional vaccines.
Why the study?
Most commercial foot-and-mouth disease vaccines have disadvantages including low antibody titers, short-lived effects, compromised host defense, and questionable safety.
Does a novel FMD vaccine containing β-D-glucan improve innate and adaptive immune responses in mice and pigs?
Does a novel FMD vaccine containing β-D-glucan improve innate and adaptive immune responses in mice and pigs?
Absolute Event Rate: 100% vs 60%
A novel FMD vaccine containing β-D-glucan as an adjuvant enhances innate and adaptive immune responses in preclinical models, offering a potential improvement over conventional vaccines.
Background Most commercial foot-and-mouth disease (FMD) vaccines have various disadvantages, such as low antibody titers, short-lived effects, compromised host defense, and questionable safety. Objectives To address these shortcomings, we present a novel FMD vaccine containing Dectin-1 agonist, β-D-glucan, as an immunomodulatory adjuvant. The proposed vaccine was developed to effectively coordinate innate and adaptive immunity for potent host defense against viral infection. Methods We demonstrated β-D-glucan mediated innate and adaptive immune responses in mice and pigs in vitro and in vivo . The expressions of pattern recognition receptors, cytokines, transcription factors, and co-stimulatory molecules were promoted via FMD vaccine containing β-D-glucan. Results β-D-glucan elicited a robust cellular immune response and early, mid-, and long-term immunity. Moreover, it exhibited potent host defense by modulating host’s innate and adaptive immunity. Conclusion Our study provides a promising approach to overcoming the limitations of conventional FMD vaccines. Based on the proposed vaccine’s safety and efficacy, it represents a breakthrough among next-generation FMD vaccines.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2023) studied Foot-and-mouth disease. FMD vaccine containing beta-D-glucan vs. Conventional FMD vaccine without beta-D-glucan (PC) or PBS (NC) was evaluated on Survival rate against FMDV type O challenge in mice. The FMD vaccine containing beta-D-glucan provided 100% survival in mice and complete protection against clinical symptoms in pigs following FMDV challenge, outperforming conventional vaccines.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: