Elderly ADHF patients with low GNRI and low MMSE had a 116% increased risk of composite outcome compared to those with high GNRI and high MMSE (HR 2.16).
Does the combination of low nutritional status (GNRI <92) and low cognitive status (MMSE ≤23) predict worse long-term outcomes in elderly patients with acute decompensated heart failure?
Combined assessment of nutritional (GNRI) and cognitive (MMSE) status at discharge significantly improves risk stratification for long-term mortality and readmission in elderly patients with acute decompensated heart failure.
Absolute Event Rate: 0% vs 0%
Background/Objectives: Malnutrition and cognitive impairment are both common and prognostically significant in elderly patients with acute decompensated heart failure (ADHF). However, the combined impact of nutritional and cognitive status on long-term outcomes remains unclear. This study aimed to evaluate the prognostic value of the Geriatric Nutritional Risk Index (GNRI) and Mini-Mental State Examination (MMSE) in elderly patients hospitalized for ADHF. Methods: We analyzed 414 ADHF patients aged ≥65 years from the NARA-LONGEVITY study. Patients were categorized into four groups based on GNRI (≥92 or 23 or ≤23) values at discharge. The primary endpoint was a composite of all-cause mortality and HF-related readmission. Results: During a median follow-up of 37.4 months, 218 patients (52.7%) reached the composite endpoint, and 168 (40.6%) died. Patients with both low GNRI and low MMSE had significantly poorer outcomes than those with high GNRI and high MMSE (adjusted hazard ratio HR for composite outcome: 2.16; 95% CI, 1.28–3.64; p = 0.004; HR for all-cause mortality: 2.21; 95% CI, 1.22–3.99; p = 0.009). The combined prognostic impact was consistent across age subgroups. Conclusions: The combined assessment of nutritional and cognitive status using GNRI and MMSE at discharge provides additional prognostic value in elderly patients with ADHF. These findings highlight the importance of a multidimensional approach to risk stratification and personalized care planning in this population.
Nogi et al. (Tue,) reported a other. Elderly ADHF patients with low GNRI and low MMSE had a 116% increased risk of composite outcome compared to those with high GNRI and high MMSE (HR 2.16).
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