What does this research mean for the field?

The CHG index and its modified versions are associated with a higher incidence of stroke in adults with early-stage CKM syndrome. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to explore the relationship between the CHG index and the occurrence of stroke in early-stage CKM syndrome.

January 10, 2026European journal of medical research0 citationsOpen Access

Associations between the CHG index, its modified versions and incident stroke in patients with early-stage CKM syndrome: a nationwide cohort study

KLKe LiZhejiang Chinese Medical University YLYing LiSuizhou Central Hospital SJSili JiangSuizhou Central Hospital

Key Result

The CHG index and its modified versions were associated with a higher incidence of stroke in adults with early-stage CKM syndrome.

Key Points

The study aims to explore the relationship between the CHG index and the occurrence of stroke in early-stage CKM syndrome.
Nationwide cohort design
Analysis of the CHG index and its modified versions
Assessment of incident stroke in adults with early CKM syndrome
The CHG index was significantly associated with increased risk of incident stroke
Modified versions of the CHG index also showed similar associations
Findings suggest potential for using the CHG index in clinical settings for early detection of stroke

Structured PICO

Does a higher CHG index and its modified versions predict incident stroke in adults with early-stage CKM syndrome?

Population

6,836 Chinese adults aged ≥45 years with early-stage cardiovascular-kidney-metabolic (CKM) syndrome (stages 0-3), mean age 58.92, 52.78% female. Excluded: CKM stage 4, prior physician-diagnosed stroke, and missing baseline data.

Intervention

Higher baseline CHG (Cholesterol-HDL-Glucose) index and its modified versions (CHG-BMI, CHG-WC, CHG-WHtR), assessed as continuous variables and by quartiles.

Comparator

Lower baseline CHG index and its modified versions (e.g., Quartile 1 vs Quartile 4).

Outcome

Incident stroke (first-ever stroke occurring during follow-up, identified via participant self-report of physician diagnosis or treatment) over up to 9 years of follow-up.hard clinical

The CHG index and its modified versions are significantly associated with incident stroke in adults with early-stage CKM syndrome, suggesting their utility as composite metabolic markers for early risk stratification.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

The CHG index and its derivatives were consistently associated with incident stroke amongst adults in the early CKM stages, and their clinical adoption may enhance early detection and prevention of stroke events in populations with vulnerable metabolism.

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