Personalised hypertension treatment improves blood pressure control by considering individual variability in response to antihypertensives based on factors like ethnicity and genetics.
Personalised hypertension care, guided by factors such as ethnicity, genetics, and polygenic risk scores, is an evolving field that should be incorporated into future clinical guidelines.
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Purpose of review There is growing evidence that personalisation of hypertension treatment leads to better blood pressure control. This review will explore current evidence for individualised treatment of hypertension, and application of this in future guidelines. Recent findings Recent studies demonstrate considerable inter-individual variability in responses to specific antihypertensives. Factors such as ethnicity, sex, age, BMI and genetics contribute to differences in blood pressure and cardiovascular risk. There is emerging ethnicity data that may help to support targeted pharmacotherapy. Advances in genetics, particularly through large-scale genome-wide association studies (GWAS), have given us insight into individual genetic determinants of blood pressure. The development of polygenic risk scores (PRS) also show promise for future precision-guided treatment. This review will examine both intra-individual and inter-individual variability in blood pressure control and treatment response using evidence to date. Summary Personalised hypertension care is an evolving field. Our review highlights the importance of refining clinical guidelines to better account for individual differences in blood pressure and treatment response.
Tantirige et al. (Tue,) reported a other. Personalised hypertension treatment improves blood pressure control by considering individual variability in response to antihypertensives based on factors like ethnicity and genetics.
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