January 10, 2026Drugs - Real World Outcomes0 citationsOpen Access

Evaluation of Effectiveness and Safety of Telmisartan and Amlodipine Fixed-Dose Combination in Indian Patients with Hypertension: TACT-India Study

ADAshok Kumar DasSri Balaji Vidyapeeth University MTMangesh TiwaskarShilpa (India)JAJabir AbdullakuttyLourdes Hospital

Key Result

Telmisartan and amlodipine fixed-dose combination significantly reduced blood pressure and was well-tolerated in Indian patients with hypertension.

Key Points

To evaluate the effectiveness and safety of a fixed-dose combination of telmisartan and amlodipine in managing hypertension among Indian patients.
Evaluated real-world effectiveness using clinical observations
Assessed tolerance of the fixed-dose combination in a diverse patient population
Analyzed blood pressure reduction and side effects during treatment
Demonstrated significant reduction in blood pressure levels among participants
Reported high tolerance levels with minimal side effects
Supported the effectiveness of the combination in real-world settings

Structured PICO

Does a fixed-dose combination of telmisartan and amlodipine reduce systolic blood pressure in Indian patients with hypertension?

Population

6,232 Indian adults (aged ≥ 18 years) with newly diagnosed hypertension (SBP ≥ 140 mmHg and DBP ≥ 90 mmHg) or uncontrolled on monotherapy, mean age 57.11, 55.02% male.

Intervention

Fixed-dose combination of telmisartan (40 mg or 80 mg) and amlodipine 5 mg once daily for 8 weeks.

Outcome

Mean change in systolic blood pressure (SBP) from baseline to 8 weeks.surrogate

A fixed-dose combination of telmisartan and amlodipine significantly reduced blood pressure and was well-tolerated in a real-world cohort of Indian patients with hypertension.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Treatment with telmisartan and amlodipine FDC demonstrated significant antihypertensive effectiveness and was well-tolerated in the real-world among Indian patients with hypertension.

Ask AI

Helpful

Bookmark

View Full Paper