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March 31, 2009Journal of Clinical HypertensionOpen Access

The greatest least-square mean systolic/diastolic BP reductions were observed with T80 mg plus A10 mg (-26.4/-20.1 mm Hg; P<.05 compared with both monotherapies).

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Why the study?

Does telmisartan plus amlodipine combination therapy improve blood pressure reduction in adults with stage 1 or 2 hypertension compared to monotherapy?

Population

1,461 adults with stage 1 or 2 hypertension

Comparison

Telmisartan plus amlodipine combination therapy… vs Respective monotherapies and placebo

Design

RCT, randomized 4 x 4 factorial

Follow-up

8 weeks

Authors

TLThomas LittlejohnCMClaudio MajulRORafael Olvera

Discussion

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Overview

Supports initial telmisartan-amlodipine combination for hypertension; confirms additive BP-lowering efficacy versus monotherapies in this RCT.

Structured PICO

Does telmisartan plus amlodipine combination therapy improve blood pressure reduction in adults with stage 1 or 2 hypertension compared to monotherapy?

P
Population
1,461 adults with stage 1 or 2 hypertension
I
Intervention
Telmisartan (20, 40, or 80 mg) plus amlodipine (2.5, 5, or 10 mg) combination therapy for 8 weeks
C
Comparator
Respective monotherapies (telmisartan alone or amlodipine alone) and placebo (T0/A0)
O
Outcome
In-clinic blood pressure reductionssurrogate

Combination therapy with telmisartan and amlodipine provides greater blood pressure reduction than monotherapy and mitigates amlodipine-induced peripheral edema.

Cite This Study

Littlejohn et al. (2009) studied this question.

synapsesocial.com/papers/6a7f036deddee3b6110d2372https://doi.org/10.1111/j.1751-7176.2009.00098.x
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