Key result
Telmisartan plus amlodipine achieved high rates of BP goal attainment in both treatment-naïve and previously treated hypertensive patients.
Why the study?
Does telmisartan/amlodipine combination therapy reduce blood pressure in both treatment-naïve and previously treated hypertensive patients?
RCT (n=1,111)
Does telmisartan/amlodipine combination therapy reduce blood pressure in both treatment-naïve and previously treated hypertensive patients?
High-dose telmisartan/amlodipine combination therapy is highly effective and well-tolerated for blood pressure control in both treatment-naïve and previously treated hypertensive patients.
Answers are grounded in this paper and cite their sources.
Supports high-dose telmisartan/amlodipine for BP control in both naïve and treated patients; extends RCT evidence for consistent goal attainment across hypertension histories.
The subanalysis of a 4 × 4 factorial, 8-week study to evaluate the efficacy and tolerability of telmisartan (T) 40-80 mg/amlodipine (A) 5-10 mg used in treatment-naïve patients (n = 231) and patients previously treated with antihypertensive agents (n = 880). Similar blood pressure (BP) reductions were achieved with T + A, regardless of their pretreatment status. Highest reductions were achieved with T80 + A10 (treatment-naïve -26.5/-18.2 mm Hg and previously treated -25.6/-19.9 mm Hg). Most patients (treatment-naïve 72.4% and previously treated 77.6%), including those with added risk, achieved BP goal (<140/90 mm Hg) with T80 + A10. Tolerability was comparable in both groups.
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Punzi et al. (2012) conducted an RCT in Hypertension (n=1,111). Telmisartan and Amlodipine vs. Previously treated patients (compared to treatment-naïve) was evaluated on BP goal (<140/90 mm Hg) achievement with T80 + A10. Telmisartan plus amlodipine achieved high rates of BP goal attainment in both treatment-naïve and previously treated hypertensive patients.
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