What does this research mean for the field?

Antihypertensive treatment was associated with a decreased risk of serious adverse events in older adults, especially those who are frail. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To investigate how antihypertensive treatment relates to serious adverse events, considering age and frailty.

January 10, 2026PLoS Medicine0 citationsOpen Access

Correction: The association between antihypertensive treatment and serious adverse events by age and frailty: A cohort study

JSJames P SheppardPreventive Cardiology CKConstantinos KoshiarisPreventive Cardiology RSRichard Stevens

Key Result

Antihypertensive treatment was associated with a decreased risk of serious adverse events in older adults, especially those who are frail.

Key Points

To investigate how antihypertensive treatment relates to serious adverse events, considering age and frailty.
Cohort study design examining antihypertensive treatment effects
Stratification by age and frailty levels
Statistical analysis of adverse event occurrences
Observations of varying adverse event rates among different age groups
Increased adverse events noted in frail versus non-frail individuals
Recommendations for personalized treatment plans based on individual frailty and age

Structured PICO

Does antihypertensive treatment increase the risk of hospitalisation from falls and other serious adverse events in previously untreated patients with raised systolic blood pressure?

Population

3,834,056 previously untreated patients with raised systolic blood pressure

Intervention

Antihypertensive treatment prescription during a 12-month exposure period

Comparator

No antihypertensive prescription during the 12-month exposure period

Outcome

First hospitalisation with a primary diagnosis of a fall within 10 yearssafety

Antihypertensive treatment in previously untreated patients with raised systolic blood pressure is associated with an increased risk of serious adverse events such as falls, hypotension, and acute kidney injury, particularly in older and frailer patients.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

This corrects the article DOI: 10.1371/journal.pmed.1004223..

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