What question did this study set out to answer?

The study examines the global disease burden of pulmonary arterial hypertension (PAH) from 1990 to 2021, focusing on patterns and inequalities.

January 10, 2026BMC Public Health0 citationsOpen Access

Global disease burden of pulmonary arterial hypertension: patterns and inequality in 1990–2021, with projections to 2035

AGAnqi GuanCentral South University ZDZiyu DaiCentral South University JLJianing LinCentral South University

Key Result

Substantial inequalities in pulmonary arterial hypertension mortality and disability rates persist despite overall improvements in recent years.

Key Points

The study examines the global disease burden of pulmonary arterial hypertension (PAH) from 1990 to 2021, focusing on patterns and inequalities.
Analyzed global health data on PAH from 1990 to 2021.
Examined trends in mortality and disability rates.
Forecasted projections for PAH burden up to 2035.
Overall improvements in PAH mortality and disability rates were observed.
Significant regional and demographic inequalities in PAH outcomes persist.
Addressing healthcare distribution can mitigate the disease burden.

Structured PICO

Population

Global population across 204 countries and territories assessed for pulmonary arterial hypertension (PAH) burden between 1990 and 2021, including 191,808 prevalent cases in 2021.

Outcome

Global burden of pulmonary arterial hypertension, including age-standardized prevalence rate (ASPR), age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life years rate (ASDR).

While global PAH mortality and disability rates have improved significantly from 1990 to 2021, prevalence and incidence have slightly increased, with substantial disparities persisting across genders and socioeconomic regions.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Despite overall improvements in PAH mortality and disability rates, substantial inequalities persist across regions and demographic groups. Addressing aging challenges and ensuring equitable healthcare distribution will help reduce the burden.

Ask AI

Helpful

Bookmark

View Full Paper