The Passive health behavior group had a mean medication adherence of 46.4% ± 10.7%, while the Selective group exhibited a higher risk of therapy discontinuation.
Latent class analysis identified three distinct health behavior subtypes in young and middle-aged hypertensive patients, providing a framework for stratified hypertension management.
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Abstract Aim To validate behavioral subtypes among young and middle-aged hypertensive patients using latent class analysis (LCA) and assess their generalizability across populations through external validation. Methods and results We applied LCA to a derivation cohort of 2,000 adults with hypertension to classify nine health behavior indicators. Model robustness was examined with bootstrap stability testing. External validation was conducted in NHANES 2009–2010 (n = 541) using confirmatory LCA. A reproducible three-class solution emerged: Active (32.6%), Selective (28.1%), and Passive (39.3%). Demographic and clinical factors—including age, sex, education, insurance type, adverse medication symptoms, hypertension severity, time since diagnosis, number of medications, and comorbidities—were associated with class membership. Notably, the Passive group showed higher medication adherence (mean 46.4% ± 10.7%), whereas the Selective group had a greater risk of intermittent discontinuation of antihypertensive therapy. Conclusion These findings support the development of individualized intervention strategies targeting health behavior in young and middle-aged hypertensive patients, providing a scalable framework for stratified hypertension management in diverse populations.
Sun et al. (Sat,) reported a other. The Passive health behavior group had a mean medication adherence of 46.4% ± 10.7%, while the Selective group exhibited a higher risk of therapy discontinuation.
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