What question did this study set out to answer?

This research aims to identify risk factors associated with higher mortality rates in older patients with candidemia.

January 10, 2026In Vivo0 citationsOpen Access

Risk Factors of Mortality in Older Patients With Candidemia

Q: What does this research mean for the field?

Early antifungal therapy is associated with lower in-hospital mortality in older patients with candidemia compared to those who received delayed treatment. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

WCW. ChenTaoyuan Armed Forces General Hospital TCTsung-Ta ChiangNational Defense Medical Center BLBING-HONG LIUNational Kaohsiung University of Science and Technology

Key Result

Early antifungal therapy was associated with lower in-hospital mortality in older patients with candidemia compared to those who received delayed treatment.

Key Points

This research aims to identify risk factors associated with higher mortality rates in older patients with candidemia.
Analyzed mortality rates in older patients with candidemia compared to younger patients.
Identified independent risk factors through statistical analysis.
Evaluated the impact of early antifungal therapy on in-hospital mortality.
Older patients demonstrated significantly higher in-hospital mortality rates compared to younger patients.
Thrombocytopenia emerged as a key independent risk factor for increased mortality.
Early initiation of antifungal therapy correlated with reduced mortality rates in older patients.

Structured PICO

Does early antifungal therapy reduce in-hospital mortality in adult patients with candidemia?

Population

402 adults (≥18 years) with candidemia (defined as ≥1 positive blood culture for Candida species) from the MIMIC-IV database. The cohort included 175 older patients (>65 years) and 227 younger patients (≤65 years).

Intervention

Early antifungal therapy (administered within 48 hours of blood culture collection)

Comparator

Late or no antifungal therapy

Outcome

In-hospital mortalityhard clinical

Early antifungal therapy significantly reduces in-hospital mortality in patients with candidemia, while thrombocytopenia and congestive heart failure are strong independent risk factors for death.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Older patients with candidemia had higher in-hospital mortality rates than those of younger patients. Thrombocytopenia was found to be an independent risk factor, and early fungal therapy was associated with lower in-hospital mortality. Early identification of patients with candidemia and appropriate antifungal therapy are important for its treatment.

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