Beta1 coherence between T5 and T6 electrodes was lower in male children with autism spectrum disorder compared to typically developing children, indicating potential functional connectivity difference
Do resting-state EEG coherence and vagally mediated heart rate variability differ between male children with ASD and typically developing children?
Resting-state EEG coherence is altered in male children with ASD, and its association with social motivation may be moderated by vagally mediated heart rate variability.
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Other Sections Abstract INTRODUCTION METHODS RESULTS DISCUSSION CONCLUSION Acknowledgments Availability of Data and Material Conflicts of Interest Author Contributions Funding Statement Reference Objectives: The brain and autonomic nervous system are tightly interconnected and may be involved in various psychiatric conditions. We explored whether electroencephalographic (EEG) coherence and vagally mediated heart rate variability (vmHRV) differ between male children with autism spectrum disorder (ASD) and typically developing (TD) children, and how these measures are associated with the clinical characteristics of ASD. Methods: We recorded resting-state EEG and vmHRV in 14 male children with ASD and 14 TD children. The Social Responsiveness Scale (SRS) was used to assess the clinical characteristics of the ASD group. Results: vmHRV measures (root mean square of successive RR intervals RMSSD, percentage of successive RR intervals that differ by more than 50 ms pNN50, and high-frequnecy power) did not differ between the ASD and TD groups. By contrast, the beta1 coherence between the T5 and T6 electrodes (beta1 coherence T5–T6) was lower in the ASD group than in the TD group, even after correction for multiple comparisons. This coherence measure demonstrated a positive correlation with RMSSD and a negative correlation with the SRS social motivation subscale score (SRS-Motivation). Moreover, pNN50 acted as a moderator of the association between beta1 coherence (T5–T6) and SRS-Motivation. Conclusion: Resting-state EEG coherence may be associated with the clinical characteristics of ASD, and vmHRV may exert a moderating effect on this relationship. These preliminary findings suggest that the concurrent evaluation of brain and autonomic functions can be useful for elucidating the pathophysiology of ASD. Keywords : EEG; Coherence; Functional connectivity; Heart rate variability; Autism spectrum disorder.
Jeon et al. (Thu,) reported a other. Beta1 coherence between T5 and T6 electrodes was lower in male children with autism spectrum disorder compared to typically developing children, indicating potential functional connectivity difference.