Recent advances in nonlinear science, mathematical modeling, and data-driven approaches are providing new insights into disease progression and early intervention strategies for biological systems.The detection and treatment of pre-disease states-the critical transitions between health and disease-represent one of the most challenging yet promising frontiers in modern medicine.This special section addresses recent progress in the field of nonlinear theory and related areas, with applications to ultra-early medicine.
Kitajima et al. (Wed,) studied this question.