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January 10, 2026Cardiovascular Diabetology2 citationsOpen Access

SCORE2-diabetes for predicting coronary artery disease: a cardiac CT study in a diabetic moderate-risk region population

RMRocco MollaceMNMatteo NardinMAMatteo Arzenton

Key Result

Higher SCORE2-D scores in patients with type 2 diabetes correlate with increased CAD burden and more severe stenosis, indicating its value in risk stratification.

Key Points

  • This study aims to evaluate the effectiveness of SCORE2-D in predicting coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM).
  • Conducted a cardiac CT scan on a moderate-risk diabetic population.
  • Evaluated and classified coronary artery disease burden and stenosis severity.
  • Assessed the relationship between SCORE2-D scores and plaque features.
  • Higher SCORE2-D scores correlate with greater CAD burden.
  • More severe stenosis is observed in individuals with increased SCORE2-D scores.
  • High-risk plaque features are predominant in patients with elevated SCORE2-D scores.

Structured PICO

Does the SCORE2-Diabetes risk score correlate with the presence, severity, and morphology of coronary artery disease on CCTA in patients with type 2 diabetes?

P
Population
104 adults (aged 40-69 years) with established type 2 diabetes mellitus (T2DM) and no prior history of ASCVD referred for CCTA due to symptoms suggestive of stable CAD. Mean age 60.7 years, 69% male. Single-center in Italy. Key exclusions: prior MI, PCI, CABG, or documented coronary plaques.
I
Intervention
SCORE2-Diabetes (SCORE2-D) risk score calculation
C
Comparator
Comparison across SCORE2-D risk categories (low, moderate, high, very high)
O
Outcome
Presence, morphology (calcific vs non-calcific), and severity of coronary plaques assessed by coronary computed tomography angiography (CCTA)surrogate

The SCORE2-Diabetes risk score significantly correlates with the presence, severity, and vulnerability of coronary plaques on CCTA, suggesting its utility in refining pre-test probability for CAD in diabetic patients.

Abstract

Higher SCORE2-D scores correlate with greater CAD burden, more severe stenosis, and a predominance of high-risk plaque features in patients with T2DM. These findings suggest that SCORE2-D may be a valuable tool in refining cardiovascular risk stratification and guiding clinical decision-making in diabetic populations.

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Cite This Study

Mollace et al. (2025) studied this question. Higher SCORE2-D scores in patients with type 2 diabetes correlate with increased CAD burden and more severe stenosis, indicating its value in risk stratification.

synapsesocial.com/papers/6963221091e05aa366cb884chttps://doi.org/10.1186/s12933-025-03000-3
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