Systolic and diastolic blood pressure, abdominal obesity, and alcohol consumption contribute to the risk of hypertrophic and dilated cardiomyopathies in European and East Asian populations

Key Result

Higher systolic blood pressure is a causal risk factor for hypertrophic cardiomyopathy, while higher diastolic blood pressure, waist circumference, and alcohol consumption increase risk for dilated ca

Key Points

• The research aims to identify causal risk factors for hypertrophic and dilated cardiomyopathies across different populations.
• Cross-ancestry genetic evidence analysis
• Association of systolic and diastolic blood pressure, abdominal obesity, and alcohol consumption with cardiomyopathy
• Population analysis in European and East Asian groups
• Higher systolic blood pressure is found to be a causal risk factor for hypertrophic cardiomyopathy.
• Diastolic blood pressure, abdominal obesity, and alcohol consumption are shown as causal risk factors for dilated cardiomyopathy.
• Findings emphasize the importance of targeting these factors for prevention strategies.