What question did this study set out to answer?

To evaluate the effectiveness of dietary management and aerobic exercise counseling in lowering blood pressure in individuals with prehypertension and drug-naïve stage 1 hypertension.

January 10, 2026Scientific Reports0 citationsOpen Access

Dietary management and aerobic exercise counselling on blood pressure control in subjects with prehypertension and drug-naïve stage 1 hypertension: a randomized clinical trial

SLSubin Lim SHSoon Jun Hong JKJu Hyeon Kim

Key Result

Dietary management and aerobic exercise counseling reduced office systolic blood pressure by 15.1 mmHg and diastolic blood pressure by 6.68 mmHg compared to the control group after 12 weeks.

Key Points

To evaluate the effectiveness of dietary management and aerobic exercise counseling in lowering blood pressure in individuals with prehypertension and drug-naïve stage 1 hypertension.
Conducted a multicenter, open-label, randomized clinical trial
Enrolled 70 participants with prehypertension and drug-naïve stage 1 hypertension
Compared dietary & exercise counseling group with a control group
Measured primary outcome as change in systolic and diastolic BP after 12 weeks
The intervention group had a significant reduction in office systolic BP by 15.1 mmHg
Diastolic BP decreased by 6.68 mmHg in the intervention group
No significant change in 24-hour ambulatory systolic BP
Subgroup analysis indicated better outcomes for females and older participants with higher baseline BP

Structured PICO

Does diet and aerobic exercise counseling reduce blood pressure in participants with prehypertension and drug-naïve stage 1 hypertension?

Population

70 participants with prehypertension and drug-naïve stage 1 hypertension (office SBP 130-159 mmHg and/or DBP 85-99 mmHg), mean age mid-50s, 64% male, in South Korea.

Intervention

Diet (DASH) and aerobic exercise counseling and monitoring (clinic visits at weeks 4 and 8, phone calls at weeks 2, 6, 10; prescribed aerobic exercise minimum 5 days/week, 60 min/session) for 12 weeks.

Comparator

Control group (no specific intervention mentioned).

Outcome

Change in systolic and diastolic blood pressure by using office BP measurements after 12 weeks.surrogate

Dietary management and aerobic exercise counseling significantly reduced office systolic and diastolic blood pressure, but not 24-hour ambulatory blood pressure, in patients with prehypertension and drug-naïve stage 1 hypertension.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

While lifestyle modification is recommended as first-line treatment for lowering blood pressure (BP) in individuals with prehypertension and drug-naïve stage 1 hypertension, there is a paucity of randomized controlled data on such subjects. This multicenter, open-label, randomized clinical trial enrolled 70 participants (N = 35 per group) with prehypertension and drug-naïve stage 1 hypertension, defined as a systolic BP (SBP) of 130-159 mmHg and/or a diastolic BP (DBP) of 85-99 mmHg. The diet dietary approaches to stop hypertension) and regular physical exercise for 12 weeks. The primary outcome was the change in systolic and diastolic BP after 12 weeks. Secondary outcomes included the 24-hour BP and its components and inflammatory markers. Compared with the control group, office SBP and DBP were reduced in the D&E group by 15.1 (-8.73 vs. 6.38 mmHg, p = 0.003) and 6.68 (-4.57 vs. 2.11 mmHg, p = 0.003) mmHg, respectively. The 24-hour ambulatory SBP did not change significantly in either group after 12 weeks (-0.72 vs. 1.92 mmHg, p = 0.667). In subgroup analysis, female, older-age participants and participants with higher baseline BP showed higher reductions in office SBP. Positive effects on office BP were noted by dietary and exercise education, especially in female and older-age participants.Trial registration: 15/05/2022, NCT05274971.

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