January 10, 2026Medicina0 citationsOpen Access
Impact of Periprocedural Risk Predictors on Long-Term Outcomes in Patients with Diabetes Undergoing Coronary Artery Bypass Grafting
Key Result
Patients with diabetes undergoing isolated CABG had a 13.5% incidence of all-cause death versus 10.6% in non-diabetics (HR 1.3, p = 0.013), indicating poorer long-term outcomes.
Key Points
- This study aims to evaluate how certain risk predictors affect long-term outcomes in diabetes patients undergoing CABG.
- Included all consecutive patients undergoing isolated CABG from May 2005 to June 2021
- Compared baseline demographics and pre-operative characteristics between diabetic and non-diabetic patients
- Used propensity-matched analysis to examine outcomes
- Primary outcome measured was long-term incidence of all-cause death
- Among 4871 total patients, 1589 pairs were identified after propensity matching
- Diabetic patients had a 13.5% incidence of all-cause death compared to 10.6% for non-diabetic patients (HR 1.3, p = 0.013)
- MACCE occurrence was significantly higher in diabetic patients (HR 1.3, p = 0.049)
- Diabetes was identified as an independent predictor for all-cause mortality (HR 1.4, CI 1.2, 1.7)
Structured PICO
Does the presence of diabetes mellitus increase the risk of long-term all-cause death and MACCE in patients undergoing isolated CABG?
P
Population
4,871 consecutive patients undergoing isolated coronary artery bypass grafting (CABG) between May 2005 and June 2021 (propensity-matched to 1,589 pairs of patients with and without diabetes)
I
Intervention
Presence of diabetes mellitus
C
Comparator
Absence of diabetes mellitus
O
Outcome
Long-term incidence of all-cause deathhard clinical
Diabetes mellitus is an independent predictor of worse long-term survival and higher MACCE rates following isolated CABG.
Main Result
Absolute Event Rate: 0% vs 0%
Abstract
Background and Objectives: In this study, we aim to analyze the impact of risk predictors on long-term outcomes in patients with diabetes undergoing isolated coronary artery bypass grafting (CABG). Materials and Methods: All consecutive patients undergoing isolated CABG between May 2005 and June 2021 were included in the study. Patients with and without diabetes were compared for baseline demographics and pre-operative characteristics. A propensity-matched analysis was used to compare the two groups. The primary outcome was long-term incidence of all-cause death. Results: Of a total of 4871 patients, propensity matching identified 1589 pairs of patients with and without diabetes that were included in the current study. Median follow-up was 5.8 years. All-cause death was recorded in 215/1589 (13.5%) vs. 169/1589 (10.6%) patients with and without diabetes, respectively (HR 1.3, p = 0.013). MACCE was also significantly higher in diabetic patients (HR 1.3, p = 0.049). Diabetes mellitus was identified as one of the independent predictors for all-cause mortality (HR 1.4, CI 1.2, 1.7) and MACCE (HR 1.2, CI 1.0, 1.3). Chronic obstructive pulmonary disease, peripheral vascular disease, and serum creatinine levels >2.0 mg/dL were found to be the only predictors of all-cause mortality in both diabetic and non-diabetic patient groups, when individually analyzed. Conclusions: Patients with diabetes undergoing isolated CABG had a significantly higher incidence of late all-cause death and MACCE compared to those without diabetes. The presence of diabetes mellitus predicts poorer long-term outcomes following CABG.