Key result
Genomic identification of inherited conditions proves crucial for managing adult sudden cardiac arrest and arrhythmias.
Why the study?
In adult cardiovascular emergencies, genetic causes have often not been considered or were deemed beyond diagnostic capabilities despite advancements in genomics capability and accessibility.
Design
Review
Supports considering genetic referrals in select adult cardiovascular emergencies; leaves open the need for prospective validation before routine adoption.
There is a growing intersection between genomics and emergency medical care following recent advancements in both capability and accessibility. This is of particular significance in the management of cardiovascular emergencies, where conditions such as sudden cardiac arrest, cardiac arrhythmia and syncope can be due to an inherited condition. The ability to identify a genetic cause for such presentations challenges what may have previously been conceded as a ‘known unknown’. This has often been the case in adult presentations, where a genetic cause may not be considered or deemed beyond available diagnostic capabilities. The purpose of this article is to inform emergency medicine clinicians about the role of genomics in adult and paediatric cardiovascular emergencies and provide a practical guide to recognising relevant presentations where referral to a cardiovascular genomic service may be relevant.
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Navaratnam et al. (2025) studied this question. Genomic identification of inherited conditions is crucial in managing adult cardiovascular emergencies like sudden cardiac arrest and arrhythmias.
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