High-dose intravenous methylprednisolone pulse therapy increased plasma levels of natriuretic peptides and significantly elevated E wave velocity in patients.
Does high-dose intravenous methylprednisolone pulse therapy acutely alter cardiac filling and function indices in patients?
High-dose intravenous methylprednisolone pulse therapy acutely increases cardiac preload, as evidenced by elevated natriuretic peptides and echocardiographic filling indices.
Absolute Event Rate: 0% vs 0%
The current study investigated acute circulatory dynamics changes induced by high-dose intravenous methylprednisolone pulse therapy (steroid pulse therapy). Eight patients who underwent steroid pulse therapy were included in the study. After steroid pulse therapy, plasma levels of brain and atrial natriuretic peptides were significantly increased compared with those before steroid pulse therapy (both p p = 0.055). Left atrial volume index (LAVI) also increased after steroid pulse therapy (p p p = 0.09). These findings indicate that steroid pulse therapy may increase cardiac preload, as suggested by the observed increases in LVDd, LAVI, and E wave velocity. Clinicians should remain mindful of this potential effect when administering steroid pulse therapy.
Nawata et al. (Sun,) reported a other. High-dose intravenous methylprednisolone pulse therapy increased plasma levels of natriuretic peptides and significantly elevated E wave velocity in patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: