Tumor invasion depth (pT1 vs pT2) did not significantly impact five-year disease-free survival (83.5% vs 83.2%, P = 0.79) or overall survival after surgery for colon cancer.
Does tumor invasion depth (pT1 vs pT2) affect survival outcomes in patients undergoing surgery for colon cancer?
Tumor invasion depth (pT1 vs pT2) does not significantly impact disease-free or overall survival following formal oncological resection for colon cancer.
Absolute Event Rate: 0% vs 0%
BACKGROUND: Organ preservation is gaining attention, yet primary treatment approaches differ substantially between pT1 and pT2 colon cancer (CC). This study evaluates whether tumor invasion depth affects survival outcomes in patients with pT1-2N0-2 colon cancer. METHODS: In this nationwide cohort study, patients undergoing surgery for pT1 or pT2 CC between 2014 and 2015 were identified from the Dutch Snapshot Research Group's SNAPSHOT complex colon cancer database. Five-year disease-free survival (DFS) and overall survival (OS) was analyzed using Kaplan-Meier curves, log-rank tests, and Cox proportional hazard models. RESULTS: A total of 2312 patients were included (921 pT1 and 1391 pT2). Five-year DFS (83.5% vs. 83.2%, P = 0.79, adjusted HR [HR CONCLUSIONS: Tumor invasion depth (pT1 or pT2) had no significant impact on DFS or OS following formal oncological resection. Furthermore, most distant metastases develop in pN0 patients, suggesting a minor influence of surgery on control of distant disease.
Hanevelt et al. (Wed,) reported a other. Tumor invasion depth (pT1 vs pT2) did not significantly impact five-year disease-free survival (83.5% vs 83.2%, P = 0.79) or overall survival after surgery for colon cancer.
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