CD160+ intraepithelial lymphocytes and CCRL2+ macrophages play distinct roles in the repair processes of cardiac versus liver injuries in adult mice.
Cardiac and liver injuries drive distinct immune microenvironments, with the heart recruiting macrophages and neutrophils while the liver accumulates lymphocytes.
Absolute Event Rate: 0% vs 0%
The regenerative capacities of organs in adult mammals vary significantly. Unlike the liver, which possesses remarkable regenerative potential, the repair of cardiac injuries has long posed a critical medical challenge. Recent studies have highlighted the pivotal role of the immune microenvironment in repairing damage in these tissues, but the key cell types and their mechanisms of action remain incompletely understood. In this study, we established a model of concurrent physical trauma to the hearts and livers of adult mice, revealing that these two injured tissues drive distinct immune microenvironments. The liver primarily accumulates lymphocytes, whereas the heart recruits macrophages and neutrophils. Notably, CD160
Sun et al. (Wed,) reported a other. CD160+ intraepithelial lymphocytes and CCRL2+ macrophages play distinct roles in the repair processes of cardiac versus liver injuries in adult mice.
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