Differential associations of cumulative average metabolic score for insulin resistance with heart disease and stroke: a prospective cohort study of middle-aged and older Chinese adults

Figures

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  Fig. 1. Flowchart of the study population. FBG, fasting blood glucose; TG, triglyceride; BMI, body mass index; HDL-c, high-density lipoprotein cholesterol; METS-IR, metabolic score for insulin resistance; Q1, Quartile 1; Q2, Quartile 2; Q3, Quartile 3; Q4, Quartile 4

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  Fig. 2. Incidence rates of CVD categorized by quartiles of the cumulative average METS-IR. Q1, Quartile 1; Q2, Quartile 2; Q3, Quartile 3; Q4, Quartile4; METS-IR, metabolic score for insulin resistance

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  Fig. 3. Association between the cumulative average METS-IR and incident CVD. The model was adjusted for gender , age, residence, education level, marital status, smoking status, drinking status, kidney disease, liver disease, SBP, DBP, hypertension, diabetes, HbA1c, TC, LDL-c, WBC, Hb, MCV, PLT, CRP, UA, Scr and BUN. SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycosylated hemoglobin A1c; TC, total cholesterol; LDL-c, low-density lipoprotein cholesterol; WBC, white blood cell; Hb, hemoglobin; MCV, mean corpuscular volume; PLT, platelet; CRP, c-reactive protein; UA, uric acid; Scr, serum creatinine; BUN, blood urea nitrogen; METS-IR, metabolic score for insulin resistance, OR, odds ratio; CI, confidence interval

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  Fig. 4. Association between the cumulative average METS-IR and incident heart condition. The model was adjusted for gender , age, residence, education level, marital status, smoking status, drinking status, kidney disease, liver disease, SBP, DBP, hypertension, diabetes, HbA1c, TC, LDL-c, WBC, Hb, MCV, PLT, CRP, UA, Scr and BUN. SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycosylated hemoglobin A1c; TC, total cholesterol; LDL-c, low-density lipoprotein cholesterol; WBC, white blood cell; Hb, hemoglobin; MCV, mean corpuscular volume; PLT, platelet; CRP, c-reactive protein; UA, uric acid; Scr, serum creatinine; BUN, blood urea nitrogen; METS-IR, metabolic score for insulin resistance, OR, odds ratio; CI, confidence interval

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  Fig. 5. Association between the cumulative average METS-IR and incident stroke. The model was adjusted for gender , age, residence, education level, marital status, smoking status, drinking status, kidney disease, liver disease, SBP, DBP, hypertension, diabetes, HbA1c, TC, LDL-c, WBC, Hb, MCV, PLT, CRP, UA, Scr and BUN. SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycosylated hemoglobin A1c; TC, total cholesterol; LDL-c, low-density lipoprotein cholesterol; WBC, white blood cell; Hb, hemoglobin; MCV, mean corpuscular volume; PLT, platelet; CRP, c-reactive protein; UA, uric acid; Scr, serum creatinine; BUN, blood urea nitrogen; METS-IR, metabolic score for insulin resistance, OR, odds ratio; CI, confidence interval

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  Fig. 6. Subgroup analyses of the association between the cumulative average METS-IR and CVD incidence. The model was adjusted for gender , age, residence, education level, marital status, smoking status, drinking status, kidney disease, liver disease, SBP, DBP, hypertension, diabetes, HbA1c, TC, LDL-c, WBC, Hb, MCV, PLT, CRP, UA, Scr and BUN (excluding the variable for subgroup stratification). SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycosylated hemoglobin A1c; TC, total cholesterol; LDL-c, low-density lipoprotein cholesterol; WBC, white blood cell; Hb, hemoglobin; MCV, mean corpuscular volume; PLT, platelet; CRP, c-reactive protein; UA, uric acid; Scr, serum creatinine; BUN, blood urea nitrogen; OR, odds ratio;CI, confidence interval