What question did this study set out to answer?

The study aims to explore the relationship between cumulative insulin resistance and cardiovascular disease outcomes in older Chinese adults.

January 10, 2026Nutrition & Metabolism0 citationsOpen Access

Differential associations of cumulative average metabolic score for insulin resistance with heart disease and stroke: a prospective cohort study of middle-aged and older Chinese adults

CYChun YangAnhui Medical University ZGZeng GuoAnhui Medical University MMMengqing MaAnhui Medical University

Key Result

Cumulative insulin resistance assessed by METS-IR is an independent predictor of cardiovascular disease in middle-aged and older Chinese adults.

Key Points

The study aims to explore the relationship between cumulative insulin resistance and cardiovascular disease outcomes in older Chinese adults.
Prospective cohort design
Enrollment of middle-aged and older Chinese adults
Assessment of cumulative insulin resistance using METS-IR
Analysis of heart disease and stroke incidence
Cumulative insulin resistance predicted cardiovascular disease, particularly heart disease.
Higher METS-IR scores correlated with increased risk of stroke.
Findings underscore the importance of early risk assessment for targeted prevention.

Structured PICO

Does a higher cumulative average metabolic score for insulin resistance (METS-IR) increase the risk of incident cardiovascular disease in middle-aged and older Chinese adults?

Population

5,264 middle-aged and older Chinese adults (aged ≥ 45 years) from the China Health and Retirement Longitudinal Study (CHARLS), mean age 58.50, 46.6% male. Key exclusion: baseline cardiovascular disease.

Intervention

Higher cumulative average metabolic score for insulin resistance (METS-IR) (Quartiles 2-4 or per 1 SD increase)

Comparator

Lowest quartile (Quartile 1) of cumulative average METS-IR

Outcome

Incident cardiovascular disease (CVD), defined as self-reported physician-diagnosed stroke or heart disease or undergoing disease-specific treatment, over a 4-year follow-uphard clinical

Cumulative exposure to insulin resistance, quantified by METS-IR, is an independent predictor of incident cardiovascular disease, particularly heart disease, in middle-aged and older Chinese adults.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Cumulative exposure to insulin resistance, quantified by METS-IR, is an independent predictor of CVD, especially heart disease, in middle-aged and older Chinese adults. Our findings highlight the clinical utility of longitudinal METS-IR assessment for early risk stratification and pinpoint specific high-risk populations for targeted preventive strategies.

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