Correction for Piliper et al., “Clinical validation of an RSV neutralization assay and analysis of cross-sectional sera associated with 2021–2023 RSV outbreaks to investigate the immunity debt hypothesis”

We discovered that calculation of titers for 10 serum samples run in the same batch on the same day failed to account for a 20-fold pre-dilution. All 10 specimens were from RSV PCR-positive individuals in the emergency department (ED), including 7 immunocompetent and 3 immunosuppressed individuals. Correction of the values for the pre-dilution leads to a 20-fold increase in the final titers for specimens from Individuals in Table S6: 06B4, 131F, 0646, 0CF5, 06E0, 029D, 11DB, 085B, 130E, and 0DEE. While comprehensively reviewing all data due to pre-dilution issue, we also found one specimen for individual 0786 from the RSV PCR-positive immunocompetent cohort that should not have passed QC and subsequently removed this specimen’s data from the analysis. The increased titers in these individuals significantly reduced the variance of RSV nAb titers in these cohorts and led to more statistically significant differences among individuals recently infected with RSV compared to the general population and individuals who later developed RSV infection, as one would hypothesize. We have updated Figure 3,