Post-bariatric surgery, 11 transition regulators interact with IGF1 signaling to promote AP6-cell transdifferentiation toward fibroblastoid lineages.
Single-nucleus RNA sequencing reveals microenvironmental reprogramming in thermogenic adipose tissue after bariatric surgery, highlighting IGF1 signaling pathways as potential therapeutic targets for obesity.
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We delineate post-bariatric microenvironmental reprogramming in thermogenic adipose depots and highlight a candidate pathway in which 11 putative transition regulators cooperate with IGF1 signaling to promote AP6-cell transdifferentiation toward fibroblastoid lineages. These data nominate testable targets for therapeutic modulation of obesity and its complications. Given the limited sample size, findings are descriptive and hypothesis-generating; definitive lineage inference awaits validation by fate mapping or RNA-velocity in larger cohorts.
Wang et al. (Mon,) reported a other. Post-bariatric surgery, 11 transition regulators interact with IGF1 signaling to promote AP6-cell transdifferentiation toward fibroblastoid lineages.