What question did this study set out to answer?

To evaluate the efficacy and long-term outcomes of the pericardio-peritoneal window for managing malignant pericardial effusion.

January 10, 2026Journal of Clinical MedicineOpen Access

Recurrent Malignant Pericardial Effusion Management: The Pericardio-Peritoneal Window

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Key result

Pericardio-peritoneal window prevents relapse requiring further procedures in ~96% of malignant pericardial effusion patients.

Why the study?

Malignant pericardial effusion is challenging to manage, and the efficacy and long-term outcomes of pericardio-peritoneal window creation as a definitive therapeutic strategy required investigation.

Does pericardio-peritoneal window creation prevent recurrent malignant pericardial effusion in patients with solid tumors?

Population

44 consecutive patients undergoing pericardio-peritoneal window creation for malignant pericardial effusion

Comparison

Pericardio-peritoneal window procedure

Design

Retrospective and prospective observational cohort study

Authors

AMAntonio MazzellaRipamonti GCG CaffarenaThe University of Texas MD Anderson Cancer Center CBClaudia BardoniIstituti di Ricovero e Cura a Carattere Scientifico

Discussion

Member takes

Implication

Supports pericardio-peritoneal window consideration in malignant pericardial effusion; extends observational data but randomized trials needed before practice change.

Key Points

To evaluate the efficacy and long-term outcomes of the pericardio-peritoneal window for managing malignant pericardial effusion.
Retrospective and prospective observation of patient data from 2010 to 2023.
Surgical procedures involved the creation of a pericardio-peritoneal window.
Analyzed complications, mortality rates, and relapse incidences post-surgery.
44 patients underwent the pericardio-peritoneal window procedure.
30-day mortality rate was 9% with no intraoperative deaths.
Recurrence of pericardial effusion noted in 8 patients within six months with a 95.5% success rate for preventing further procedures.

Structured PICO

Does pericardio-peritoneal window creation prevent recurrent malignant pericardial effusion in patients with solid tumors?

Population

44 consecutive patients with malignant pericardial effusion (MPE) treated at the European Institute of Oncology (IEO) from 2010 to December 2023

Intervention

Pericardio-peritoneal window (PPW) creation

Outcome

Efficacy and long-term outcomes (surgical procedures needed, total and specific postoperative complications, 30-day mortality rate, relapse rate, and the treatment of possible relapses)hard clinical

Pericardio-peritoneal window creation is a safe and effective definitive therapeutic strategy for resolving malignant pericardial effusion, with a high success rate in preventing relapse requiring further procedures.

Cite This Study

Mazzella et al. (2025) studied this question. The pericardio-peritoneal window achieved a 95.5% success rate in preventing pericardial relapse requiring further procedures in patients with malignant pericardial effusion.

synapsesocial.com/papers/6963223491e05aa366cb8d02 https://doi.org/10.3390/jcm15010083

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Implication

Supports pericardio-peritoneal window consideration in malignant pericardial effusion; extends observational data but randomized trials needed before practice change.

Recurrent Malignant Pericardial Effusion Management: The Pericardio-Peritoneal Window

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Recurrent Malignant Pericardial Effusion Management: The Pericardio-Peritoneal Window

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider