What question did this study set out to answer?

The study aims to identify novel genes involved in hypertension-driven mechano-immune interactions that influence IA rupture progression.

January 10, 2026International Journal of Data Mining and Bioinformatics0 citationsOpen Access

Hypertension-driven mechano-immune crosstalk related novel genes may be potential targets for IA rupture progression

JLJi Yun LiuXian Yang Central Hospital JYJun YuanNortheastern University LLLi Luo

Key Points

The study aims to identify novel genes involved in hypertension-driven mechano-immune interactions that influence IA rupture progression.
Analyzed gene expression profiles related to hypertension and IA rupture.

Structured PICO

Population

55 samples (29 ruptured intracranial aneurysm cases vs. 26 unruptured controls) pooled from three GEO datasets (GSE13353, GSE26969, GSE75436), plus GWAS summary statistics for unruptured and ruptured intracranial aneurysms.

Outcome

Identification of characteristic genes for UIA-to-IA progression using LASSO regression and ROC curve analysissurrogate

Bioinformatic analysis identified ITGAX, JAM3, KLHL28, TOGARAM1, and MAGI2 as novel potential molecular targets for hypertension-driven intracranial aneurysm rupture progression.

Abstract

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