What question did this study set out to answer?

This research aims to identify clinical and molecular predictors of brain metastases in colorectal cancer patients.

January 14, 2026Journal of Clinical Oncology

Which patients with colorectal cancer develop brain metastases? A multicenter analysis of clinical and molecular predictors.

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This research aims to identify clinical and molecular predictors of brain metastases in colorectal cancer patients.
Retrospective review of colorectal cancer patients treated at eight oncology centers.
Analysis of clinical variables such as age, sex, and tumor location, along with molecular markers.
Mortality and survival outcomes measured from CRC diagnosis and after brain metastasis development.
1.7% of colorectal cancer patients developed brain metastases, primarily from left-sided and rectal tumors.
Higher rates of HER2 positivity and prevalence of specific mutations like KRAS and BRAF were observed.
Median overall survival from diagnosis was 31.2 months; post-brain metastasis survival was only 4.8 months.

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Implication

Multicenter analysis shows brain metastases in colorectal cancer linked to left-sided tumors and HER2 positivity, suggesting need for targeted strategies.

Cite This Study

Kemik et al. (2026) studied this question.

synapsesocial.com/papers/6966e6f513bf7a6f02bff039 https://doi.org/10.1200/jco.2026.44.2_suppl.218

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Implication

Multicenter analysis shows brain metastases in colorectal cancer linked to left-sided tumors and HER2 positivity, suggesting need for targeted strategies.

Which patients with colorectal cancer develop brain metastases? A multicenter analysis of clinical and molecular predictors.

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Discussion

Implication

Cite This Study

Which patients with colorectal cancer develop brain metastases? A multicenter analysis of clinical and molecular predictors.

Key Points

Discussion

Implication

Cite This Study

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