Iridium-catalyzed 5+1 cyclization of terminal alkynes with CF3-imidoyl sulfoxonium ylides to construct 2-trifluoroquinolines

Key Points

• This research aims to develop a new synthetic strategy for creating 2-trifluoroquinolines.
• Iridium-catalyzed [5+1] cyclization methodology
• Utilization of CF3-imidoyl sulfoxonium ylides
• Combination with terminal alkynes
• Successfully synthesized a series of multi-substituted 2-trifluoroquinolines
• Demonstrated efficacy of the iridium catalyst in the cyclization process.