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This research demonstrates a novel synthesis of 2-trifluoroquinolines using iridium-catalyzed cyclization of alkynes and ylides, indicating efficient production of various quinolines.
Reported herein is a novel strategy for the synthesis of 2-trifluoroquinolines by iridium-catalyzed [5+1] cyclization of CF3-imidoyl sulfoxonium ylides with terminal alkynes. A series of multi-substituted quinolines were successfully obtained...
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Mi et al. (2026) studied this question.
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