Developing a cascade difluoroalkylation process in quinazolin derivatives, highlighting an innovative dual cyclization method.
A photoinduced cascade difluoroalkylation/cyclization reaction of arylethynyl quinazolin-4(3H)-ones with ethyl iododifluoroacetates or iododifluoramides has been developed. This transformation enables the construction of difluoroalkylated quinolino[2,1-b]quinazoline derivatives via consecutive intramolecular dual cyclization...
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Yao et al. (2025) studied this question.
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