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Efficient logP determination by automated, spatially encoded 19 F NMR Spectroscopy | Synapse

January 14, 2026RSC Medicinal Chemistry0 citationsOpen Access

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Efficient logP determination by automated, spatially encoded 19 F NMR Spectroscopy

SWSusanna Wood FGF. GordonLa Trobe University RSRobin S. SteinUniversité Claude Bernard Lyon 1

Key Points

To establish an efficient method for directly determining logP using 19F NMR spectroscopy.
Utilized slice-selective 19F NMR spectroscopy
Employed a single partitioned NMR sample of n-octanol/water
Focused on the direct determination of logP
Achieved straightforward logP determination
Indicated potential improvements in efficiency and accuracy of measurement

Abstract

We report a straightforward method for direct determination of logP by slice-selective 19F NMR spectroscopy utilising a single NMR sample. Our technique uses a partitioned NMR sample of n-octanol/water containing...

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Cite This Study

Wood et al. (Thu,) studied this question.

synapsesocial.com/papers/6966e70113bf7a6f02bff2ce https://doi.org/https://doi.org/10.1039/d5md00678c