Neutrophil‐to‐Lymphocyte Ratio Predicts Anxiety Progression in Parkinson's Disease

Background Anxiety progression in Parkinson's disease (PD) and its link to peripheral inflammation remain unclear. Objective This study aimed to determine whether lymphocyte‐related inflammatory markers can predict the longitudinal progression of anxiety symptoms in patients with PD. Methods This study utilized a large public database to evaluate 13 inflammatory markers associated with lymphocytes. Linear regression and mixed‐effects models were employed to assess associations between the inflammatory indicators and anxiety symptoms. Results Elevated baseline neutrophil‐to‐lymphocyte ratio (NLR), systemic immune‐inflammation index (SII), and systemic inflammation response index (SIRI) were associated with higher levels of both state and trait anxiety ( P < 0.05). An increase in the NLR is indicative of the deterioration of trait anxiety (estimate = 0.455, P = 0.030), especially in late‐onset PD (LOPD) patients and males. Conclusions The NLR is a potential biomarker for the progression of anxiety in PD patients, indicating that neuroinflammation is related to anxiety.